The synthesis difference between stapled peptide and the normal linear peptide lies in being introduced the two non natural amino acids containing a-methyl and a-alkenyl in the process of solid phase synthesis.Then the two non natural amino acids occur olefin metathesis cyclization to form stable a-helix conformation of the carbon to synthesize stapled peptide.
Below,the red coloring depicts a peptide with helix, and the green coloring mean the hydrocarbon staple. Rendering based on PDB 4MZK. A stapled peptides with multiple, tandem staples are sometimes referred to as stitched peptides Peptide staple is used to enhance pharmacologic performance of peptides.
The synthetic route of stapled peptide :
Bankpeptide always adheres to the customer first business philosophy. Through accumulation of long years experiment, constantly optimization of the synthesis conditions and the purification technology, we already have a mature method of stapled peptide synthesis to provide highquality stapled peptides fully meeting the needs of customers in different kinds of research and development area.
Each peptide is shipped with a Document of HPLC and MS data for free. Other test datas can also be provided according to customer demand . Peptides are packed with ice bag and desiccants during shipment and storage. After opening, we recommend peptides are stored dry in a freezer (details given in our technical guide to handling peptides; a copy is shipped with each peptide).

a.What is the minimum quantity for a peptide?

The minimun for one peptide should be 1mg, and there is no maximum quantity for a peptide at Bankpeptide.

b.Which kind of solvent should I use?

According to your needs, the peptides can often dissolved in water, DMF,DMSO, and PBS Buffer.

Mature Technology
Success rate 99.99%
Competitive price
Rush peptide service
Ordering & Contact Information
  • Get quote

  • Place your order

  • Production Start

  • Pass the QA

  • Sent to the Customer

Please contact us for additional information or send an email to
You may also request an online quote as follow:
The way we support payment is T/T and Paypal.

Please click here to receive a quote now!


"Phase 1 Safety Study of ALRN-5281 in Healthy Subjects". ClinicalTrials. U.S. National Institutes of Health. Retrieved 23 July 2015. Chu, Qian; Moellering, Raymond E.; Hilinski, Gerard J.; Kim, Young-Woo; Grossmann, Tom N.; Yeh,Johann es T.-H.; Verdine, Gregory L. (2015). "Towards understanding cell penetration by stapled peptides". Med. Chem. Commun. 6 (1): 111–119.

PHONE:+86-551-62626599-802 803 805


COMPANY ADDRESS:Floor 4,C6 Science and Technology Industrial Park, No. 168 Xiangzhang  Road, Hefei hi-tech Dist, Anhui province, China