The synthesis difference between stapled peptide and the normal linear peptide lies in being introduced the two non natural amino acids containing a-methyl and a-alkenyl in the process of solid phase synthesis.Then the two non natural amino acids occur olefin metathesis cyclization to form stable a-helix conformation of the carbon to synthesize stapled peptide.

Below,the red coloring depicts a peptide with helix, and the green coloring mean the hydrocarbon staple. Rendering based on PDB 4MZK. A stapled peptides with multiple, tandem staples are sometimes referred to as stitched peptides Peptide staple is used to enhance pharmacologic performance of peptides.

Bankpeptide always adheres to the customer first business philosophy. Through accumulation of long years experiment, constantly optimization of the synthesis conditions and the purification technology, we already have a mature method of stapled peptide synthesis to provide highquality stapled peptides fully meeting the needs of customers in different kinds of research and development area.

Each peptide is shipped with a Document of HPLC and MS data for free. Other test datas can also be provided according to customer demand . Peptides are packed with ice bag and desiccants during shipment and storage. After opening, we recommend peptides are stored dry in a freezer (details given in our technical guide to handling peptides; a copy is shipped with each peptide).