Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients. Beta amyloid peptide consists of 43 amino acids. It is created via the enzymatic digestion of amyloid precursor protein (APP) by beta secretase and gamma secretase. It then forms insoluble fibrous aggregates, causing amyloidosis and neurodegenerative diseases such as AD. Due to beta amyloid's involvement in the pathogenic process of AD, it has become one of the most investigated molecules in AD research projects.
Bankpeptide synthesis platform allows us to synthesize a comprehensive array of human and rat beta amyloid peptide fragments covering stretches of its amino acid sequence. This can ease the process of elucidating the potential biological interactions of each specific fragment. Bankpeptide's philosophy of continuous improvement and dedication to a cure for AD and other diseases can make us a valuable partner in your mission.
Label Attribute
Calatog Num1·ber BP001
Synonyms Abeta 1-28
Product Description Beta amyloid is an extracellular filamentous protein deposit found in the brain. It is the major protein component of amyloid cores and neuritic plaques and is also found as a deposit in neurofibrillary tangles. Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). Beta-amyloid peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process.
CAS No. 109770-29-8
Purity ≥ 95% by HPLC
Molecular Weight 3262.5
Formula C145H209N41O46
Storage -20 °C
Sequence (Three-Letter Code) Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys
Solubility Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
Citations Gorbita CH. The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's beta-amyloid polypeptide. Chem. Commun(Camb). Jun 2006; 14(22 ): 2332-2334. 
Song Y, et al. Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain. Histol. Hist opathol. Jul 2006; 21(7): 705-711. 
Park HY, et al. Modulation of neutrophil apoptosis by beta-amyloid proteins. Int. Immunopharmacol. Jul 2006; 6(7): 1061-1069. 
Label Attribute
Calatog Number BP002
Synonyms Β-Amyloid; b-Amyloid; b-Amyloid; beta-Amyloid; beta-Amyloidβ-Amyloid
Product Description Beta amyloid (42-1) is the reverse of beta amyloid (1-42), the latter is a member of beta amyloid-peptides, which are involved in the amyloid beta-peptide (A beta)-associated f ree radical oxidative stress model for neuronal death in Alzheimer's disease (AD) brain.
Purity ≥ 95% by HPLC
Molecular Weight 4514.4
Formula C203H311N55O60S1
Storage -20 °C
Sequence (Three-Letter Code) Ala-Ile-Val-Val-Gly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp-Glu-Ala-Phe-Phe-Val-Leu-Lys-Gln-His-His-Val-Glu-Tyr-Gly-Ser-Asp-His-Arg-Phe-Glu-Ala-Asp
Citations Anderson OA., etc. A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome. PLoS One. 2013Jun;8(6):e67263. 
Label Attribute
Calatog Num1·ber BP003
Synonyms Diabetes-Associated Peptide (DAP), amide, humanInsulinoma or islet amyloid polypeptide (IAPP)
Product Description Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be res ponsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin. Amylin blocks the activation of glycogen synth ase by insulin.
Purity ≥ 95% by HPLC
Molecular Weight 3903.28
Formula C165H261N51O55S2
Disulfide Bridge Disulfide Bridge: Cys2-Cys7
Storage -20 °C
Sequence (Three-Letter Code) Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2
Solubility Can be dissolved in DMSO or DMF first and then dilute with water
Citations Konarkowska B, et al. Thiol reducing compounds prevent human amylin-evoked cytotoxicity. FEBS J. Oct 2005; 272(19): 4949-4959.
Kajava AV, et al. The parallel superpleated beta-structure as a model for amyloid fibrils of human amylin. J. Mol. Biol. Apr 2005; 348(2): 247-252.
Guerreiro LH., etc. Polymeric particles for the controlled release of human amylin. Colloids Surf B Biointerfaces. 2012 Jun;94:101-6.
Kevin Hartman., etc. Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences. PeerJ. 2013 Feb;12(1):e5.
Label Attribute
Calatog Num1·ber BP004
Product Description Beta amyloid 1-42 is known as a biomarker of Alzheimer's disease. Amyloid is detectable in cerebrospinal fluid (CSF). It is a 42-amino acid fragment of amyloid precursor protei n. The peptide is well suited for use as a standard in the quantitation of Alzheimer's.
CAS No. 107761-42-2
Purity ≥ 95% by HPLC
Molecular Weight 4514.14
Formula C203H311N55O60S1
Storage -20 °C
Sequence (Three-Letter Code) Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-I le-Ala
Solubility Soluble in water
Citations Ambroggio EE, et al. Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide. Biophys J. Apr 2005; 88(4): 2706-2713.
Mathew A., etc. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS One.2012 Mar;7(3):e32616.
R Banerjee. etc. Effect of Curcumin on the metal ion induced fibrillization of Amyloid-β peptide. Spectrochim Acta A Mol Biomol Spectrosc.2013 Sep;
Anila Mathew etc. Amyloid-Binding Aptamer Conjugated Curcumin-PLGA Nanoparticle for Potential Use in Alzheimer’s Disease. BioNanoScience. 2012 Jun; 2 (2); 83-93.
Label Attribute
Calatog Num1·ber BP005
Synonyms Abeta 1-42, ratβ-Amyloid Peptide;
Product Description Abeta 1-42 induces a strong membrane destabilization in giant unilamellar vesicles composed of palmitoyloleoyl-phosphatidylcholine, sphingomyelin, and cholesterol, lowering the critical tension of vesicle rupture. Additionally, Abeta 1-42 triggers the induction of sequential leakage of low- and high-molecular-weight markers trapped inside the giant unilamellar vesicles, but preserving the vesicle shape. The Abeta 1-42 sequence confers particular molecular properties to the peptide that, in turn, influence supramolecularpro perties associated with membranes that may result in toxicity,including: 1) the ability of the peptide to strongly associate with the membrane; 2) a reduction of lateral membrane cohesive forces; and 3) a capacity to break the transbilayer gradient and puncture sealed vesicles.
Purity ≥ 95% by HPLC
Molecular Weight 4418.1
Formula C199H307N53O59S1
Storage -20 °C
Sequence (Three-Letter Code) Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Citations Folin M, et al. Apolipoprotein-E modulates the cytotoxic effect of beta-amyloid on rat brain endothelium in an isoform-dependent specific manner. Int J Mol Med. May 2006;17(5 ):821-826.
Chen L, et al. alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats. Neuropharmacology. Feb 2006;50(2 ):254-268.
Bastianetto S, et al. Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. Eur J Neurosci. Jan 2006;23(1):55-64.

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